Humoral Immunogenicity and Efficacy of a Single Dose of ChAdOx1 MERS Vaccine Candidate in Dromedary Camels
Identifieur interne : 000542 ( Main/Exploration ); précédent : 000541; suivant : 000543Humoral Immunogenicity and Efficacy of a Single Dose of ChAdOx1 MERS Vaccine Candidate in Dromedary Camels
Auteurs : Naif Khalaf Alharbi [Arabie saoudite] ; Ibrahim Qasim [Arabie saoudite] ; Abdulrahman Almasoud [Arabie saoudite] ; Haya A. Aljami [Arabie saoudite] ; Mohamed W. Alenazi [Arabie saoudite] ; Ali Alhafufi [Arabie saoudite] ; Omar S. Aldibasi [Arabie saoudite] ; Anwar M. Hashem [Arabie saoudite] ; Samy Kasem [Arabie saoudite, Égypte] ; Raed Albrahim [Arabie saoudite] ; Musaad Aldubaib [Arabie saoudite] ; Ali Almansour [Arabie saoudite] ; Nigel J. Temperton ; Alexandra Kupke [Allemagne] ; Stephan Becker [Allemagne] ; Ali Abu-Obaidah [Arabie saoudite] ; Ali Alkarar [Arabie saoudite] ; In-Kyu Yoon [Corée du Sud] ; Esam Azhar [Arabie saoudite] ; Teresa Lambe ; Faisal Bayoumi [Arabie saoudite] ; Ali Aldowerij [Arabie saoudite] ; Osman H. Ibrahim [Arabie saoudite] ; Sarah C. Gilbert ; Hanan H. Balkhy [Arabie saoudite]Source :
- Scientific Reports [ 2045-2322 ] ; 2019.
Abstract
MERS-CoV seronegative and seropositive camels received a single intramuscular dose of ChAdOx1 MERS, a replication-deficient adenoviral vectored vaccine expressing MERS-CoV spike protein, with further groups receiving control vaccinations. Infectious camels with active naturally acquired MERS-CoV infection, were co-housed with the vaccinated camels at a ratio of 1:2 (infected:vaccinated); nasal discharge and virus titres were monitored for 14 days. Overall, the vaccination reduced virus shedding and nasal discharge (p = 0.0059 and p = 0.0274, respectively). Antibody responses in seropositive camels were enhancedby the vaccine; these camels had a higher average age than seronegative. Older seronegative camels responded more strongly to vaccination than younger animals; and neutralising antibodies were detected in nasal swabs. Further work is required to optimise vaccine regimens for younger seronegative camels.
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DOI: 10.1038/s41598-019-52730-4
PubMed: 31705137
PubMed Central: 6841732
Affiliations:
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Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Alkarar, Ali" sort="Alkarar, Ali" uniqKey="Alkarar A" first="Ali" last="Alkarar">Ali Alkarar</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Ministry of Environment, Water and Agriculture (MEWA), Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Ministry of Environment, Water and Agriculture (MEWA), Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Yoon, In Kyu" sort="Yoon, In Kyu" uniqKey="Yoon I" first="In-Kyu" last="Yoon">In-Kyu Yoon</name><affiliation wicri:level="1"><nlm:aff id="Aff11"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9629 885X</institution-id><institution-id institution-id-type="GRID">grid.30311.30</institution-id><institution>International Vaccine Institute,</institution></institution-wrap>Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Azhar, Esam" sort="Azhar, Esam" uniqKey="Azhar E" first="Esam" last="Azhar">Esam Azhar</name><affiliation wicri:level="1"><nlm:aff id="Aff13"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0619 1117</institution-id><institution-id institution-id-type="GRID">grid.412125.1</institution-id><institution>Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences,</institution><institution>King Abdulaziz University,</institution></institution-wrap>Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Jeddah</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff14"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0619 1117</institution-id><institution-id institution-id-type="GRID">grid.412125.1</institution-id><institution>Special Infectious Agents Unit, King Fahd Medical Research Center,</institution><institution>King Abdulaziz University,</institution></institution-wrap>Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Jeddah</wicri:regionArea></affiliation></author><author><name sortKey="Lambe, Teresa" sort="Lambe, Teresa" uniqKey="Lambe T" first="Teresa" last="Lambe">Teresa Lambe</name><affiliation><nlm:aff id="Aff15"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id><institution-id institution-id-type="GRID">grid.4991.5</institution-id><institution>The Jenner Institute,</institution><institution>University of Oxford,</institution></institution-wrap>Oxford, OX3 7DQ UK</nlm:aff><wicri:noCountry code="subfield">OX3 7DQ UK</wicri:noCountry></affiliation></author><author><name sortKey="Bayoumi, Faisal" sort="Bayoumi, Faisal" uniqKey="Bayoumi F" first="Faisal" last="Bayoumi">Faisal Bayoumi</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Ministry of Environment, Water and Agriculture (MEWA), Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Ministry of Environment, Water and Agriculture (MEWA), Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Aldowerij, Ali" sort="Aldowerij, Ali" uniqKey="Aldowerij A" first="Ali" last="Aldowerij">Ali Aldowerij</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Ministry of Environment, Water and Agriculture (MEWA), Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Ministry of Environment, Water and Agriculture (MEWA), Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Ibrahim, Osman H" sort="Ibrahim, Osman H" uniqKey="Ibrahim O" first="Osman H." last="Ibrahim">Osman H. Ibrahim</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Ministry of Environment, Water and Agriculture (MEWA), Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Ministry of Environment, Water and Agriculture (MEWA), Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Gilbert, Sarah C" sort="Gilbert, Sarah C" uniqKey="Gilbert S" first="Sarah C." last="Gilbert">Sarah C. Gilbert</name><affiliation><nlm:aff id="Aff15"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id><institution-id institution-id-type="GRID">grid.4991.5</institution-id><institution>The Jenner Institute,</institution><institution>University of Oxford,</institution></institution-wrap>Oxford, OX3 7DQ UK</nlm:aff><wicri:noCountry code="subfield">OX3 7DQ UK</wicri:noCountry></affiliation></author><author><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H." last="Balkhy">Hanan H. Balkhy</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0580 0891</institution-id><institution-id institution-id-type="GRID">grid.452607.2</institution-id><institution>Department of Infectious Disease Research,</institution><institution>King Abdullah International Medical Research Center,</institution></institution-wrap>Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Riyadh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0608 0662</institution-id><institution-id institution-id-type="GRID">grid.412149.b</institution-id><institution>King Saud bin Abdulaziz University for Health Sciences,</institution></institution-wrap>Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Riyadh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff16"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0607 2419</institution-id><institution-id institution-id-type="GRID">grid.416641.0</institution-id><institution>Department of Infection Prevention and Control,</institution><institution>Ministry of National Guard - Health Affairs,</institution></institution-wrap>Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Riyadh</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31705137</idno><idno type="pmc">6841732</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6841732</idno><idno type="RBID">PMC:6841732</idno><idno type="doi">10.1038/s41598-019-52730-4</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000463</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000463</idno><idno type="wicri:Area/Pmc/Curation">000463</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000463</idno><idno type="wicri:Area/Pmc/Checkpoint">000286</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000286</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:31705137</idno><idno type="wicri:Area/PubMed/Corpus">000370</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000370</idno><idno type="wicri:Area/PubMed/Curation">000370</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000370</idno><idno type="wicri:Area/PubMed/Checkpoint">000532</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000532</idno><idno type="wicri:Area/Ncbi/Merge">002394</idno><idno type="wicri:Area/Ncbi/Curation">002394</idno><idno type="wicri:Area/Ncbi/Checkpoint">002394</idno><idno type="wicri:Area/Main/Merge">000545</idno><idno type="wicri:Area/Main/Curation">000542</idno><idno type="wicri:Area/Main/Exploration">000542</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Humoral Immunogenicity and Efficacy of a Single Dose of ChAdOx1 MERS Vaccine Candidate in Dromedary Camels</title><author><name sortKey="Alharbi, Naif Khalaf" sort="Alharbi, Naif Khalaf" uniqKey="Alharbi N" first="Naif Khalaf" last="Alharbi">Naif Khalaf Alharbi</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0580 0891</institution-id><institution-id institution-id-type="GRID">grid.452607.2</institution-id><institution>Department of Infectious Disease Research,</institution><institution>King Abdullah International Medical Research Center,</institution></institution-wrap>Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Riyadh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0608 0662</institution-id><institution-id institution-id-type="GRID">grid.412149.b</institution-id><institution>King Saud bin Abdulaziz University for Health Sciences,</institution></institution-wrap>Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Riyadh</wicri:regionArea></affiliation></author><author><name sortKey="Qasim, Ibrahim" sort="Qasim, Ibrahim" uniqKey="Qasim I" first="Ibrahim" last="Qasim">Ibrahim Qasim</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Ministry of Environment, Water and Agriculture (MEWA), Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Ministry of Environment, Water and Agriculture (MEWA), Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Almasoud, Abdulrahman" sort="Almasoud, Abdulrahman" uniqKey="Almasoud A" first="Abdulrahman" last="Almasoud">Abdulrahman Almasoud</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0580 0891</institution-id><institution-id institution-id-type="GRID">grid.452607.2</institution-id><institution>Department of Infectious Disease Research,</institution><institution>King Abdullah International Medical Research Center,</institution></institution-wrap>Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Riyadh</wicri:regionArea></affiliation></author><author><name sortKey="Aljami, Haya A" sort="Aljami, Haya A" uniqKey="Aljami H" first="Haya A." last="Aljami">Haya A. Aljami</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0580 0891</institution-id><institution-id institution-id-type="GRID">grid.452607.2</institution-id><institution>Department of Infectious Disease Research,</institution><institution>King Abdullah International Medical Research Center,</institution></institution-wrap>Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Riyadh</wicri:regionArea></affiliation></author><author><name sortKey="Alenazi, Mohamed W" sort="Alenazi, Mohamed W" uniqKey="Alenazi M" first="Mohamed W." last="Alenazi">Mohamed W. Alenazi</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0580 0891</institution-id><institution-id institution-id-type="GRID">grid.452607.2</institution-id><institution>Department of Infectious Disease Research,</institution><institution>King Abdullah International Medical Research Center,</institution></institution-wrap>Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Riyadh</wicri:regionArea></affiliation></author><author><name sortKey="Alhafufi, Ali" sort="Alhafufi, Ali" uniqKey="Alhafufi A" first="Ali" last="Alhafufi">Ali Alhafufi</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Ministry of Environment, Water and Agriculture (MEWA), Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Ministry of Environment, Water and Agriculture (MEWA), Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Aldibasi, Omar S" sort="Aldibasi, Omar S" uniqKey="Aldibasi O" first="Omar S." last="Aldibasi">Omar S. Aldibasi</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0580 0891</institution-id><institution-id institution-id-type="GRID">grid.452607.2</institution-id><institution>Department of Bioinformatics and Biostatistics,</institution><institution>King Abdullah International Medical Research Center,</institution></institution-wrap>Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Riyadh</wicri:regionArea></affiliation></author><author><name sortKey="Hashem, Anwar M" sort="Hashem, Anwar M" uniqKey="Hashem A" first="Anwar M." last="Hashem">Anwar M. Hashem</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0619 1117</institution-id><institution-id institution-id-type="GRID">grid.412125.1</institution-id><institution>Department of Medical Microbiology and Parasitology,</institution><institution>Faculty of Medicine, King Abdulaziz University,</institution></institution-wrap>Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Jeddah</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0619 1117</institution-id><institution-id institution-id-type="GRID">grid.412125.1</institution-id><institution>Vaccines and Immunotherapy Unit, King Fahd Medical Research Center,</institution><institution>King Abdulaziz University,</institution></institution-wrap>Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Jeddah</wicri:regionArea></affiliation></author><author><name sortKey="Kasem, Samy" sort="Kasem, Samy" uniqKey="Kasem S" first="Samy" last="Kasem">Samy Kasem</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Ministry of Environment, Water and Agriculture (MEWA), Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Ministry of Environment, Water and Agriculture (MEWA), Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0578 3577</institution-id><institution-id institution-id-type="GRID">grid.411978.2</institution-id><institution>Department of Virology, Faculty of Veterinary Medicine,</institution><institution>Kafrelsheikh University,</institution></institution-wrap>Kafrelsheikh, El Geish Street, 33516 Egypt</nlm:aff><country xml:lang="fr">Égypte</country><wicri:regionArea>Kafrelsheikh, El Geish Street</wicri:regionArea><wicri:noRegion>El Geish Street</wicri:noRegion></affiliation></author><author><name sortKey="Albrahim, Raed" sort="Albrahim, Raed" uniqKey="Albrahim R" first="Raed" last="Albrahim">Raed Albrahim</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Ministry of Environment, Water and Agriculture (MEWA), Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Ministry of Environment, Water and Agriculture (MEWA), Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Aldubaib, Musaad" sort="Aldubaib, Musaad" uniqKey="Aldubaib M" first="Musaad" last="Aldubaib">Musaad Aldubaib</name><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9421 8094</institution-id><institution-id institution-id-type="GRID">grid.412602.3</institution-id><institution>College of Agriculture and Veterinary Medicine,</institution><institution>Qassim University,</institution></institution-wrap>Qassim, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Qassim</wicri:regionArea></affiliation></author><author><name sortKey="Almansour, Ali" sort="Almansour, Ali" uniqKey="Almansour A" first="Ali" last="Almansour">Ali Almansour</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Ministry of Environment, Water and Agriculture (MEWA), Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Ministry of Environment, Water and Agriculture (MEWA), Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Temperton, Nigel J" sort="Temperton, Nigel J" uniqKey="Temperton N" first="Nigel J." last="Temperton">Nigel J. Temperton</name><affiliation><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2232 2818</institution-id><institution-id institution-id-type="GRID">grid.9759.2</institution-id><institution>Viral Pseudotype Unit, Medway School of Pharmacy,</institution><institution>University of Kent,</institution></institution-wrap>Chatham, Kent ME4 4TB United Kingdom</nlm:aff><wicri:noCountry code="subfield">Kent ME4 4TB United Kingdom</wicri:noCountry></affiliation></author><author><name sortKey="Kupke, Alexandra" sort="Kupke, Alexandra" uniqKey="Kupke A" first="Alexandra" last="Kupke">Alexandra Kupke</name><affiliation wicri:level="1"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9756</institution-id><institution-id institution-id-type="GRID">grid.10253.35</institution-id><institution>Institute of Virology, Philipps University of Marburg,</institution></institution-wrap>Marburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Marburg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff12"><institution-wrap><institution-id institution-id-type="GRID">grid.452463.2</institution-id><institution>German Center for Infection Research (DZIF),</institution></institution-wrap>Partner Site Gieβen-Marburg-Langen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Partner Site Gieβen-Marburg-Langen</wicri:regionArea></affiliation></author><author><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name><affiliation wicri:level="1"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9756</institution-id><institution-id institution-id-type="GRID">grid.10253.35</institution-id><institution>Institute of Virology, Philipps University of Marburg,</institution></institution-wrap>Marburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Marburg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff12"><institution-wrap><institution-id institution-id-type="GRID">grid.452463.2</institution-id><institution>German Center for Infection Research (DZIF),</institution></institution-wrap>Partner Site Gieβen-Marburg-Langen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Partner Site Gieβen-Marburg-Langen</wicri:regionArea></affiliation></author><author><name sortKey="Abu Obaidah, Ali" sort="Abu Obaidah, Ali" uniqKey="Abu Obaidah A" first="Ali" last="Abu-Obaidah">Ali Abu-Obaidah</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Ministry of Environment, Water and Agriculture (MEWA), Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Ministry of Environment, Water and Agriculture (MEWA), Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Alkarar, Ali" sort="Alkarar, Ali" uniqKey="Alkarar A" first="Ali" last="Alkarar">Ali Alkarar</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Ministry of Environment, Water and Agriculture (MEWA), Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Ministry of Environment, Water and Agriculture (MEWA), Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Yoon, In Kyu" sort="Yoon, In Kyu" uniqKey="Yoon I" first="In-Kyu" last="Yoon">In-Kyu Yoon</name><affiliation wicri:level="1"><nlm:aff id="Aff11"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9629 885X</institution-id><institution-id institution-id-type="GRID">grid.30311.30</institution-id><institution>International Vaccine Institute,</institution></institution-wrap>Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Azhar, Esam" sort="Azhar, Esam" uniqKey="Azhar E" first="Esam" last="Azhar">Esam Azhar</name><affiliation wicri:level="1"><nlm:aff id="Aff13"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0619 1117</institution-id><institution-id institution-id-type="GRID">grid.412125.1</institution-id><institution>Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences,</institution><institution>King Abdulaziz University,</institution></institution-wrap>Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Jeddah</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff14"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0619 1117</institution-id><institution-id institution-id-type="GRID">grid.412125.1</institution-id><institution>Special Infectious Agents Unit, King Fahd Medical Research Center,</institution><institution>King Abdulaziz University,</institution></institution-wrap>Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Jeddah</wicri:regionArea></affiliation></author><author><name sortKey="Lambe, Teresa" sort="Lambe, Teresa" uniqKey="Lambe T" first="Teresa" last="Lambe">Teresa Lambe</name><affiliation><nlm:aff id="Aff15"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id><institution-id institution-id-type="GRID">grid.4991.5</institution-id><institution>The Jenner Institute,</institution><institution>University of Oxford,</institution></institution-wrap>Oxford, OX3 7DQ UK</nlm:aff><wicri:noCountry code="subfield">OX3 7DQ UK</wicri:noCountry></affiliation></author><author><name sortKey="Bayoumi, Faisal" sort="Bayoumi, Faisal" uniqKey="Bayoumi F" first="Faisal" last="Bayoumi">Faisal Bayoumi</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Ministry of Environment, Water and Agriculture (MEWA), Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Ministry of Environment, Water and Agriculture (MEWA), Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Aldowerij, Ali" sort="Aldowerij, Ali" uniqKey="Aldowerij A" first="Ali" last="Aldowerij">Ali Aldowerij</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Ministry of Environment, Water and Agriculture (MEWA), Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Ministry of Environment, Water and Agriculture (MEWA), Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Ibrahim, Osman H" sort="Ibrahim, Osman H" uniqKey="Ibrahim O" first="Osman H." last="Ibrahim">Osman H. Ibrahim</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Ministry of Environment, Water and Agriculture (MEWA), Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Ministry of Environment, Water and Agriculture (MEWA), Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Gilbert, Sarah C" sort="Gilbert, Sarah C" uniqKey="Gilbert S" first="Sarah C." last="Gilbert">Sarah C. Gilbert</name><affiliation><nlm:aff id="Aff15"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id><institution-id institution-id-type="GRID">grid.4991.5</institution-id><institution>The Jenner Institute,</institution><institution>University of Oxford,</institution></institution-wrap>Oxford, OX3 7DQ UK</nlm:aff><wicri:noCountry code="subfield">OX3 7DQ UK</wicri:noCountry></affiliation></author><author><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H." last="Balkhy">Hanan H. Balkhy</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0580 0891</institution-id><institution-id institution-id-type="GRID">grid.452607.2</institution-id><institution>Department of Infectious Disease Research,</institution><institution>King Abdullah International Medical Research Center,</institution></institution-wrap>Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Riyadh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0608 0662</institution-id><institution-id institution-id-type="GRID">grid.412149.b</institution-id><institution>King Saud bin Abdulaziz University for Health Sciences,</institution></institution-wrap>Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Riyadh</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff16"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0607 2419</institution-id><institution-id institution-id-type="GRID">grid.416641.0</institution-id><institution>Department of Infection Prevention and Control,</institution><institution>Ministry of National Guard - Health Affairs,</institution></institution-wrap>Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Riyadh</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">MERS-CoV seronegative and seropositive camels received a single intramuscular dose of ChAdOx1 MERS, a replication-deficient adenoviral vectored vaccine expressing MERS-CoV spike protein, with further groups receiving control vaccinations. Infectious camels with active naturally acquired MERS-CoV infection, were co-housed with the vaccinated camels at a ratio of 1:2 (infected:vaccinated); nasal discharge and virus titres were monitored for 14 days. Overall, the vaccination reduced virus shedding and nasal discharge (p = 0.0059 and p = 0.0274, respectively). Antibody responses in seropositive camels were enhancedby the vaccine; these camels had a higher average age than seronegative. Older seronegative camels responded more strongly to vaccination than younger animals; and neutralising antibodies were detected in nasal swabs. Further work is required to optimise vaccine regimens for younger seronegative camels.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Reusken, Cbem" uniqKey="Reusken C">CBEM Reusken</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Deem, Sl" uniqKey="Deem S">SL Deem</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Alagaili, An" uniqKey="Alagaili A">AN Alagaili</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lu, G" uniqKey="Lu G">G Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yong, Cy" uniqKey="Yong C">CY Yong</name></author><author><name sortKey="Ong, Hk" uniqKey="Ong H">HK Ong</name></author><author><name sortKey="Yeap, Sk" uniqKey="Yeap S">SK Yeap</name></author><author><name sortKey="Ho, Kl" uniqKey="Ho K">KL Ho</name></author><author><name sortKey="Tan, Ws" uniqKey="Tan W">WS Tan</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ali, Ma" uniqKey="Ali M">MA Ali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hemida, Mg" uniqKey="Hemida M">MG Hemida</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hemida, Mg" uniqKey="Hemida M">MG Hemida</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yusof, Mf" uniqKey="Yusof M">MF Yusof</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dicks, Md" uniqKey="Dicks M">MD Dicks</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Padilla Quirarte, Ho" uniqKey="Padilla Quirarte H">HO Padilla-Quirarte</name></author><author><name sortKey="Lopez Guerrero, Dv" uniqKey="Lopez Guerrero D">DV Lopez-Guerrero</name></author><author><name sortKey="Gutierrez Xicotencatl, L" uniqKey="Gutierrez Xicotencatl L">L Gutierrez-Xicotencatl</name></author><author><name sortKey="Esquivel Guadarrama, F" uniqKey="Esquivel Guadarrama F">F Esquivel-Guadarrama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hashem, Am" uniqKey="Hashem A">AM Hashem</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Adney, Dr" uniqKey="Adney D">DR Adney</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Draper, Sj" uniqKey="Draper S">SJ Draper</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Azhar, Ei" uniqKey="Azhar E">EI Azhar</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Arabie saoudite</li><li>Corée du Sud</li><li>Égypte</li></country></list><tree><noCountry><name sortKey="Gilbert, Sarah C" sort="Gilbert, Sarah C" uniqKey="Gilbert S" first="Sarah C." last="Gilbert">Sarah C. Gilbert</name><name sortKey="Lambe, Teresa" sort="Lambe, Teresa" uniqKey="Lambe T" first="Teresa" last="Lambe">Teresa Lambe</name><name sortKey="Temperton, Nigel J" sort="Temperton, Nigel J" uniqKey="Temperton N" first="Nigel J." last="Temperton">Nigel J. Temperton</name></noCountry><country name="Arabie saoudite"><noRegion><name sortKey="Alharbi, Naif Khalaf" sort="Alharbi, Naif Khalaf" uniqKey="Alharbi N" first="Naif Khalaf" last="Alharbi">Naif Khalaf Alharbi</name></noRegion><name sortKey="Abu Obaidah, Ali" sort="Abu Obaidah, Ali" uniqKey="Abu Obaidah A" first="Ali" last="Abu-Obaidah">Ali Abu-Obaidah</name><name sortKey="Albrahim, Raed" sort="Albrahim, Raed" uniqKey="Albrahim R" first="Raed" last="Albrahim">Raed Albrahim</name><name sortKey="Aldibasi, Omar S" sort="Aldibasi, Omar S" uniqKey="Aldibasi O" first="Omar S." last="Aldibasi">Omar S. Aldibasi</name><name sortKey="Aldowerij, Ali" sort="Aldowerij, Ali" uniqKey="Aldowerij A" first="Ali" last="Aldowerij">Ali Aldowerij</name><name sortKey="Aldubaib, Musaad" sort="Aldubaib, Musaad" uniqKey="Aldubaib M" first="Musaad" last="Aldubaib">Musaad Aldubaib</name><name sortKey="Alenazi, Mohamed W" sort="Alenazi, Mohamed W" uniqKey="Alenazi M" first="Mohamed W." last="Alenazi">Mohamed W. Alenazi</name><name sortKey="Alhafufi, Ali" sort="Alhafufi, Ali" uniqKey="Alhafufi A" first="Ali" last="Alhafufi">Ali Alhafufi</name><name sortKey="Alharbi, Naif Khalaf" sort="Alharbi, Naif Khalaf" uniqKey="Alharbi N" first="Naif Khalaf" last="Alharbi">Naif Khalaf Alharbi</name><name sortKey="Aljami, Haya A" sort="Aljami, Haya A" uniqKey="Aljami H" first="Haya A." last="Aljami">Haya A. Aljami</name><name sortKey="Alkarar, Ali" sort="Alkarar, Ali" uniqKey="Alkarar A" first="Ali" last="Alkarar">Ali Alkarar</name><name sortKey="Almansour, Ali" sort="Almansour, Ali" uniqKey="Almansour A" first="Ali" last="Almansour">Ali Almansour</name><name sortKey="Almasoud, Abdulrahman" sort="Almasoud, Abdulrahman" uniqKey="Almasoud A" first="Abdulrahman" last="Almasoud">Abdulrahman Almasoud</name><name sortKey="Azhar, Esam" sort="Azhar, Esam" uniqKey="Azhar E" first="Esam" last="Azhar">Esam Azhar</name><name sortKey="Azhar, Esam" sort="Azhar, Esam" uniqKey="Azhar E" first="Esam" last="Azhar">Esam Azhar</name><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H." last="Balkhy">Hanan H. Balkhy</name><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H." last="Balkhy">Hanan H. Balkhy</name><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H." last="Balkhy">Hanan H. Balkhy</name><name sortKey="Bayoumi, Faisal" sort="Bayoumi, Faisal" uniqKey="Bayoumi F" first="Faisal" last="Bayoumi">Faisal Bayoumi</name><name sortKey="Hashem, Anwar M" sort="Hashem, Anwar M" uniqKey="Hashem A" first="Anwar M." last="Hashem">Anwar M. Hashem</name><name sortKey="Hashem, Anwar M" sort="Hashem, Anwar M" uniqKey="Hashem A" first="Anwar M." last="Hashem">Anwar M. Hashem</name><name sortKey="Ibrahim, Osman H" sort="Ibrahim, Osman H" uniqKey="Ibrahim O" first="Osman H." last="Ibrahim">Osman H. Ibrahim</name><name sortKey="Kasem, Samy" sort="Kasem, Samy" uniqKey="Kasem S" first="Samy" last="Kasem">Samy Kasem</name><name sortKey="Qasim, Ibrahim" sort="Qasim, Ibrahim" uniqKey="Qasim I" first="Ibrahim" last="Qasim">Ibrahim Qasim</name></country><country name="Égypte"><noRegion><name sortKey="Kasem, Samy" sort="Kasem, Samy" uniqKey="Kasem S" first="Samy" last="Kasem">Samy Kasem</name></noRegion></country><country name="Allemagne"><noRegion><name sortKey="Kupke, Alexandra" sort="Kupke, Alexandra" uniqKey="Kupke A" first="Alexandra" last="Kupke">Alexandra Kupke</name></noRegion><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name><name sortKey="Kupke, Alexandra" sort="Kupke, Alexandra" uniqKey="Kupke A" first="Alexandra" last="Kupke">Alexandra Kupke</name></country><country name="Corée du Sud"><noRegion><name sortKey="Yoon, In Kyu" sort="Yoon, In Kyu" uniqKey="Yoon I" first="In-Kyu" last="Yoon">In-Kyu Yoon</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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